TyVAC, a partnership between the Center for Vaccine Development at the University of Maryland School of Medicine, the Oxford Vaccine Group at the University of Oxford, and PATH, an international nonprofit, aims to accelerate the introduction of new TCVs as part of an integrated approach to reducing the burden of morbidity and mortality from typhoid in countries eligible for support from Gavi, the Vaccine Alliance (Gavi).
The TyVAC approach is multidisciplinary – at the global level, the consortium works closely with WHO, Gavi, and other stakeholders to ensure there are sufficient data and evidence to inform global guidelines, financing decisions, and a sustainable vaccine supply. Similarly, TyVAC works with local partners to support program preparation and ensure evidence-based policy decisions.
TyVAC assesses existing data and generates new evidence related to typhoid disease burden, antimicrobial resistance, cost-effectiveness, health impact analyses, and regional data on TCVs. We conduct country-level analyses to understand cost and economic value of vaccines and inform decision-makers at the national level.
International Vaccine Institute’s Enteric Fever Program aims to accelerate the development and introduction of safe, effective and affordable typhoid conjugate vaccines (TCVs) to prevent and control typhoid in developing countries.
The Coalition against Typhoid, based at the Sabin Vaccine Institute, works to prevent typhoid and other invasive salmonelloses through research, education and advocacy. With more than 800 members, the Coalition acts as a catalyst in the global health community to coordinate partnerships, convene decision-makers and advocate for sustainable solutions, including access to next-generation vaccines and clean water. The Coalition, formed in 2010, is guided by a multi-stakeholder steering committee and supported by the Bill & Melinda Gates Foundation.
The International Typhoid Consortium brought together and analysed the global collection of Salmonella Typhi. Whole genome sequencing of these samples enabled an unprecedented phylogenetic analysis of S. Typhi.