Salmonella Typhi and Paratyphi A are the causative agents of typhoid. The disease is transmitted by the consumption of contaminated food or water.
Typhoid is a global disease. Genetic studies based on DNA sequencing of S. Typhi have revealed the population structure of the pathogen at the highest resolution.
Increasing use of antibiotics has led to the emergence of Salmonella strains that are resistant to most of the currently available treatments.
Current typhoid vaccines confer protection to adults and older children over a limited time frame. A new conjugate vaccine, TyVi, promises better protection and can be administered to all age groups.