Main Content
Typhoid affects nearly 12 million people a year, resulting in over 128,000 deaths and particularly impacts the very poor.- Now is a critical time for intervention as a dominant multidrug resistant S. Typhi strain is spreading globally.
As typhoid scientists, we developed this website to provide information on what causes typhoid, where it is found, and what can be done to stop its spread.
The Disease and Salmonella
Salmonella Typhi and Paratyphi A bacteria are the causative agents of typhoid. The disease is transmitted by the consumption of contaminated food or water.
Global Family Tree
Typhoid is a global disease. Genetic studies based on DNA sequencing of S. Typhi have revealed the population structure of the pathogen at the highest resolution.
Antibiotic Resistance
Increasing use of antibiotics has led to the emergence of Salmonella strains that are resistant to most of the currently available treatments.
Vaccine Initiatives
Newly licensed Typhoid Conjugate Vaccines have longer-lasting protection, require fewer doses, and are suitable for children less than two years of age.
Global distribution of S. Typhi resistant to the three first-line antibiotics
Global distribution of S. Typhi with reduced senstivity to fluoroquinolone treatment
Global distribution of a dominant multi-drug resistant S. Typhi strain
Links to web resources to interrogate existing data collections and upload and analyze sequencing data